New research reveals that individuals who stop using new weight-loss injections like semaglutide or tirzepatide may regain reduced body mass much more quickly than those who end conventional diet and exercise plans.
Published data in a major health publication shows that while obese people often shed about a fifth of their body weight while on the medication, the weight is regained at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals using these treatments should be cognizant of the risk of quick rebound weight gain when the treatment is stopped," stated expert Dr. Susan Jebb.
Such speed of recovery suggests a return to pre-treatment mass within about 18 months.
Analyzing Approaches
The study, which reviewed 37 of studies involving thousands of participants, compared the effects of GLP-1 agonists with older methods.
The team emphasize that people who lose weight through diet and exercise usually experience a slower weight regain—perhaps 100 grams monthly—once they finish.
Understanding the Rapid Regain
Doctors suggest the mechanism of the jabs accounts for the accelerated rebound.
The injections imitate a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of GLP-1 levels far above than normal may cause the body to generate a reduced amount of its own natural hormone, and could reduce sensitivity to its effects," explained Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication means appetite is no longer kept in check, making binge eating far more likely."
A Chronic Disease?
Medical guidelines suggest the injections for people with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Professionals contend that, considering the significant potential of relapse, the treatment is often long-term.
This view is supported by pharmaceutical companies, who note that the results "underscore the chronic nature of excess weight," similar to managing conditions like high blood pressure.
User Experiences
Individuals who have stopped the jabs describe a sudden return of appetite.
"It felt as if a switch flipping and you become extremely hungry," said one woman.
This challenge is compounded if individuals have not developed lasting lifestyle or habit changes during therapy.
Growing Adoption
Figures show that a significant number of adults in the UK have tried these injections in the past year, with desire continuing to grow.
- Use is more common among females compared to men.
- The 40s and 50s age group shows the highest usage rates.
- Many access the drugs through private healthcare rather than public health services.
Finally, researchers stress that while the jabs are effective agents for weight loss, they are not a permanent cure and long-term success likely depends on ongoing behavioural support.
